UCPH as a leader in Next Generation designer organisms
The use of a novel and revolutionary genome editing technology has the power to redesign most living organisms with exquisite precision, speed and cost-effectiveness. The technologies have immense translational potential in diverse areas of biotechnology and biomedicine including drug discovery, stem cell and gene therapies, livestock, and crops, but also gives rise to serious ethical and legal implications. The vision is to transform University of Copenhagen into a leading knowledge center on precise genetic engineering of cells and organisms using novel and revolutionary nuclease-based technologies.
Engineered CHO cells for production of diverse, homogeneous glycoproteins.
Yang Z et al. (2015) Nat Biotechnol 33(8):842-4
A Strategy for O-Glycoproteomics of Enveloped Viruses—the O-Glycoproteome of Herpes Simplex Virus Type 1 .
Bagdonaite I et al. (2015) PLoS Pathog 11(4): e1004784
Fast and sensitive detection of indels induced by precise gene targeting.
Yang Z et al. (2015) Nucleic Acids Res. 19;43(9):e59
Gene editing: Advising Advice
Addison, C and Taylor-Alexander, S (2015) Science 349(6251); 935