Research – University of Copenhagen

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CDO > Research

Research

The objectives

  • Establish the infrastructure for UCPH scientists to use ZFNs/TALENs for genetic engineering of cells and organisms.
  • Exploit the DNA editing technologies to generate novel designer organisms (plants, rodents, pigs), cell factories, disease models, and stem cell therapeutics.
  • Address the pertinent ethical and legal aspects of this new technology that here-and-now makes unlimited genetic engineering of plants and animals technically feasible.

Integrate this new technology into ongoing research creating a resource center Our proposed Copenhagen Consortium for Designer Organisms (CDO) is a multidisciplinary network of established research groups at UCPH. The program has excellent synergies with established activities including the Center for Glycomics, the Transgenic Mouse Facility, the DanStem Center, and the Center for Bio- sustainability (partly at UCPH).

Porse Group
Our group has to major research interests: To provide a better understanding of the role of transcription factors in normal and malignant hematopoiesis and to characterize the importance of nonsense-mediated mRNA decay (NMD) in vivo.
Our research is centered on using mouse genetics to address basic biological problems.
http://www.bric.ku.dk/research/porse_group/

Brakebusch Group
Our aim is to understand the role of Rho GTPases in vivo during development and in diseases.  Rho GTPases are a family of 22 small GTPases which regulate the organization of the cytoskeleton, but also cell polarity, proliferation, apoptosis, cell-cell contacts and adhesion to the extracellular matrix. Although many studies have characterized Rho GTPase function in vitro, not much is known about their in vivo function.
http://www.bric.ku.dk/research/brakebusch_group/

Copenhagen Center for Glycomics - Hans Wandall, Eric Bennett & Henrik Clausen
The Center explores the saccharide chains - complex carbohydrates - that cover the surface of our proteins and cells. Complex carbohydrates are essential for fundamental cellular processes, and changes in the glycome are involved in e.g. metabolic diseases and cancers. We develop new methods to detect mutations and the changes these infer on the glycome and cellular processes. Insight into the glycome may lead to new diagnostic tools and better-targeted drugs and vaccines.
http://glycomics.ku.dk/

Frödin Group
We are interested in determining how protein kinase cascades activated by extracellular signals regulate normal cell functions and how dysregulation of these protein kinases contributes to cancer, diabetes and other important diseases. Our main expertice is protein kinase cascades downstream of the PI-3 kinase and RAS proto-oncogenes, which are activated by growth factors, insulin and, many regulatory peptides and neurotransmitters. However, we also perform “kinome-wide” screens to reveal roles of other of the 500 human or 240 Drosophila protein kinases in processes important to cancer or other diseases. In our research, we employ a wide array of techniques including functional, large-scale RNA interference screens in various cell culture model systems, biochemical and molecular cellular analysis, genome-wide approaches like Solexa/Illumina tag sequencing for mRNA expression profiling or high-resolution mapping of histone modifications important for epigenetic control of gene expression as well as gene-manipulation in mice.
http://www.bric.ku.dk/Research/Frodin_Group/

Janne Rothmar Herrmann
Our research is focused on legal regulation of (bio)technology and bioethical dilemmas. Our current research relate to the interaction between law and other areas of knowledge and regulation of technology and bioethical dilemmas in a broad sense.

Poul Hyttel; Institut for Klinisk Veterinær- og Husdyrvidenskab, Genetik, kvantitativ genetik og anatomi
                      

  

 

 

 

Peter Sandøe; Department of Large Animal Sciences/Populationsbiology
Since 1990 the major part of our research has been within bioethics with particular emphasis on ethical issues related to animals, biotechnology and food production. We are committed to interdisciplinary work combining perspectives from natural science, social sciences and philosophy.

The Glycosection, Department of Environmental and Plant Biology – Bent L. Pedersen
The group studies biosynthesis, evolution, and industrial utilization of plant cell walls and glycoproteins. The section is equipped with state of the art infrastructure for plant glyco and protein biology including state-of-the-art carbohydrate microarray facilities. Focus areas include elucidation of protein glycosylation machineries in plants, glyco engineering of plant/yeast cells with focus on targeted ZFN/Talen mediated genome editing for compatible or immunogenic (to man) type glycosylation, expression, enzymatic and structural characterization of (glyco)proteins of therapeutic interest.  (http://plen.ku.dk/english/research/Glyco/bioeng/o-glycome/).